Table 1 The statistics of the gold standard datasets used for the mouse reprogramming and human hematopoiesis studies

From: Inference of cell type-specific gene regulatory networks on cell lineages from single cell omic datasets

Dataset

Gold standards

Number of TFs

Number of targets

Mouse reprogramming

ChIP

54

31,367

 

Perturb

179

21,019

 

Perturb + ChIP

47

6109

Human hematopoiesis

Hematopoietic stem cells (HSC)

6

9173

 

CD14_monocytes

1

6523

 

megakaryocytes

4

8733

 

erythroid_progenitors

1

7955

 

R3R4_erythroid_cells

1

8494

 

macrophages

1

163

 

CD34_hematopoietic_stem_cells-derived_proerythroblasts

3

5847

 

T-cells

3

6189

 

B-cells

1

7036

 

GM_B-cells

48

10,597

Human hematopoiesis

UniBind

56

10,621

 

Cus_ChIP

149

6179

 

Cus_KO

50

6108

 

Cus_KO + Cus_ChIP

26

2124

 

Cus_KO + UniBind

12

2020

  1. For mouse reprogramming, shown are network statistics for the mouse embryonic stem cell (ESC) line from ESCAPE34 and ENCODE35 databases and Nishiyama et al.36. For the human hematopoietic studies, shown are network statistics for the gold standard datasets obtained from the UniBind database46 and Cusanovich et al.47.
Back to article page