Fig. 1: Architecture of the Rpd3L complex.
From: Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex
A Domain maps of Rpd3L subunits. Modeled regions are marked with black bars, whereas extended regions based on AlphaFold2 predictions are marked with grey bars; numbers indicate starting and ending residues. B Top: Cryo-electron microscopy (cryo-EM) map in green showing the best-defined parts of Rpd3L. A transparent lower-threshold cryo-EM map is overlaid to show the flexible density. Bottom: Cartoon representation of Rpd3L architectural features. See also Supplementary Fig. 7 for primary data relating to positional disorder for Modules I and II. C Left: Cryo-EM map of the Rpd3L core with individual subunits colored. Right: Model of the Rpd3L core with individual subunits colored and labeled.
