Fig. 3: CAPS-5 scores and negative-image-related amygdala theta activity during the Emotional Image Task decreased while daily stimulation therapy increased.
From: A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder
a Changes in CAPS-5 scores (gray) for TR-PTSD 1 during pre-stimulation (Pre-Stim) periods (baseline 1, 2, and month 1) and post-stimulation periods (Month 2–12) along with changes in mean ( ± s.e.m.) daily therapy (stimulation) counts (orange) over the same time period. Gray * = reliable change (Methods) in CAPS-5 scores according to Marx et al. in n = 1 participant17. relative to Pre-Stim CAPS-5 Scores. Blue boxes indicate time points when the Emotional Image Task was completed during Pre-Stim and Post-Stim sessions. b Same as (a) but for TR-PTSD 2. c Difference in normalized (Norm.) amygdala theta (5–9 Hz) bandpower between negative (Neg) and positive/neutral (Pos/Neu) images from the Emotional Image Task (teal) and CAPS-5 scores (gray) for TR-PTSD 1 during Pre-Stim and Post-Stim sessions. Teal * = unadjusted p < 0.001, gray * = reliable change in CAPS-5 scores according to Marx et al.17 relative to Pre-Stim CAPS-5 Scores. d Same as (c) but for TR-PTSD 2. Teal * = Pre-Stim unadjusted p = 0.008, Post-Stim 1 unadjusted p = 0.038, gray * = reliable change in CAPS-5 scores according to Marx et al.17 relative to Pre-Stim CAPS-5 Scores. Squares = TR-PTSD 1, triangles = TR-PTSD 2.
