Fig. 4: IFNγ neutralization does not affect the activation phenotypic profile of CAR.CD19-T cells. | Nature Communications

Fig. 4: IFNγ neutralization does not affect the activation phenotypic profile of CAR.CD19-T cells.

From: Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies

Fig. 4

Phenotypic analysis on different activation markers expressed by T cells (NT or CAR.CD19) after 16 h of co-cultures with Daudi cells either in the presence or absence of 100 μg/ml emapalumab. Data are expressed as mean ± SD and obtained by three independent experiments, with CAR.CD19-T cells generated by three different donors. Student’s t-test was employed to evaluate the statistical relevance of the differences between groups. Data were compared by a two-tailed Student t-test and p value <0.05 was considered statistically significant. Source data are provided as a Source Data file.

Back to article page