Fig. 2: Tumor protection in PtenS380A/A and PtenΔ4/ Δ4 mice despite AKT signaling.
a Overall and (b) tumor-specific incidence of tumors at 9 months in FVB mice of indicated genotypes. Number of mice (n) for (a–c) is indicated in (a). Incidence of specific tumors is based on macroscopic screening. “Other tumors” include lipomas and tumors in breast, uterus and liver. Photos above graph show examples of below graphed tumors. c Incidence at 9 months of lymphadenopathy. We note that the incidence in +/+ was 0%. Photo depicts an example of lymphadenopathy in a submandibular lymph node of a Pten+/– mouse. d, e As (a, b) but now at 16 months, number of mice is indicated in (d). Pten+/– mice typically don’t reach 16 months of age and are therefore excluded. f WBs of lysates from indicated tissues and genotypes harvested at 2 months and probed with indicated antibodies. Blot is representative of at least 3 individual samples. Ponceau S (PonS) staining served as loading control. Statistical significance was assessed by two-sided Fisher’s exact test compared to +/+. Scale bars are 5 mm. Source data are provided as a Source Data file.
