Fig. 1: Regioselective alkylation of unsymmetrical ketones. | Nature Communications

Fig. 1: Regioselective alkylation of unsymmetrical ketones.

From: Ketone α-alkylation at the more-hindered site

Fig. 1

a Conventional alkylation of ketones and composition of enolate mixtures generated by various bases. LDA lithium diisopropylamide, KHMDS potassium bis(trimethylsilyl)amide. b Proposed strategy for selective alkylation reaction at the more-hindered α-site. L ligand. c Scope of this allylic alkylation reaction.

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