Fig. 3: The scope of unsymmetrical ketones. | Nature Communications

Fig. 3: The scope of unsymmetrical ketones.

From: Ketone α-alkylation at the more-hindered site

Fig. 3: The scope of unsymmetrical ketones.The alternative text for this image may have been generated using AI.

Reaction conditions: Ni(COD)2 (10 mol%), L6 (11 mol%), EtOH (0.5 mL), ketone 1 (0.1 mmol), allylic alcohol 2a (0.1 mmol), 80 °C, 12 h. Isolated yields are given. r.r. > 99:1 unless noted. a Ketones with primary and tertiary α-carbons. b Ketones with secondary and tertiary α-carbons. c Ketones with primary and secondary α-carbons. Ketone 1 (0.3 mmol), allylic alcohol 2a (0.1 mmol). Using iPrOH as solvent.

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