Fig. 5: Applications of nickel-catalyzed allylic alkylation of unsymmetrical ketones. | Nature Communications

Fig. 5: Applications of nickel-catalyzed allylic alkylation of unsymmetrical ketones.

From: Ketone α-alkylation at the more-hindered site

Fig. 5: Applications of nickel-catalyzed allylic alkylation of unsymmetrical ketones.The alternative text for this image may have been generated using AI.

a Regioselective allylic alkylation on a gram scale. Ketone 1h (5.0 mmol), allylic alcohol 2a (5.0 mmol). b Regioselective and chemoselective allylic alkylation of ketones. Ketone (0.3 mmol), allylic alcohol 2a (0.1 mmol). c Late-stage modification of natural and bioactive ketones. Reaction conditions: Ni(COD)2 (10 mol%), L6 (11 mol%), ketone (0.1 mmol), allylic alcohol (0.1 mmol), iPrOH (0.5 mL). aUsing EtOH as solvent.

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