Fig. 2: Homozygosity and inbreeding across different cohorts.
From: South Asian medical cohorts reveal strong founder effects and high rates of homozygosity
a Observed/expected proportions of rare homozygotes, stratified by minor allele frequency and population. The expected values assume random mating. b Stacked bar chart showing the estimated degree of inbreeding for individuals in the South Asian medical cohorts. c Same as in panel a but for “inbred” individuals (whose parents are estimated to be third-degree relatives or more closely related) only. d Same as in panel a but for “outbred” individuals (whose parents are estimated to be sixth-degree relatives or more distantly related) only. e Ridgeplots showing the distribution across individuals of the total (genetic) length of the genome contained in ROHs that are at least 1 cM in length. f Ridgeplots showing the stratification of panel e’s PKN plot into groups with different estimated degrees of inbreeding.
