Fig. 2: SARS-CoV-2 variant replication dynamics and tropism in index mice. | Nature Communications

Fig. 2: SARS-CoV-2 variant replication dynamics and tropism in index mice.

From: A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

Fig. 2

a Neonatal K18-hACE2+/- mice were infected with indicated SARS-CoV-2 and viral shedding samples were collected daily. At 2 dpi, retrotracheal lavages and lungs were collected to determine viral titers and heads were fixed for immunohistochemistry. b–g Viral burden in daily shedding samples (left) and at 2 dpi in shedding samples, upper respiratory tract and lungs (right). Individual values below the limit of detection (LOD, 50 PFU/ml) were set to 5. Data from at least 2 independent repetitions with n = 6 - 15 pups per group. Only significant p-values (Kruskal-Wallis test) are presented. h Immunohistochemistry for SARS-CoV-2 N at 2 dpi in nasopharynx. Created with BioRender.com.

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