Fig. 8: TRABID expression correlates negatively with an anti-tumor immune microenvironment across diverse cancer types. | Nature Communications

Fig. 8: TRABID expression correlates negatively with an anti-tumor immune microenvironment across diverse cancer types.

From: TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation

Fig. 8

a Heatmap showing the correlation of TRABIID gene expression level with the expression levels of indicated genes. Data were retrieved from TCGA datasets. Cancer types are labeled on the x axis. P value are determined by Pearson’s correlation. b, c Heatmap showing the correlation of TRABID gene expression levels with the infiltration of indicated anti-tumor (b) or pro-tumor (c) immune cells. Correlations were obtained through the TIMER2.0 website. Cancer types and immune cells types are labeled on the x and y axes, respectively. P value are determined by Spearman’s correlation. d Schematic representation for the role of TRABID targeting in the activation of cGAS/STING pathway to trigger anti-tumor immunity and ICB sensitization. Source data are provided as a Source Data file.

Back to article page