Fig. 5: Percent variance explained of individual adjustments for pairs of outcomes, with estimates shown by cohort. | Nature Communications

Fig. 5: Percent variance explained of individual adjustments for pairs of outcomes, with estimates shown by cohort.

From: Evidence against a temporal association between cerebrovascular disease and Alzheimer’s disease imaging biomarkers

Fig. 5: Percent variance explained of individual adjustments for pairs of outcomes, with estimates shown by cohort.The alternative text for this image may have been generated using AI.

Values shown are R2 with 95% credible intervals. Estimates computed from models fit on each of two cohorts: MCSA + ADRC shown in the orange circle and ADNI in a blue triangle. In the statistical analyses, each participant was a unique observation, and the number of participants varies across the comparisons based on data availability. For the MCSA + ADRC: amyloid PET SUVR with tau PET SUVR (n = 1440), amyloid PET SUVR with WMH% (n = 2383), amyloid PET SUVR with FA GCC (n = 2006), tau PET SUVR with WMH% (n = 1417), tau PET SUVR with FA GCC (n = 1119), and FA GCC with WMH% (n = 2004). For ADNI: amyloid PET SUVR with tau PET SUVR (n = 660), amyloid PET SUVR with WMH% (n = 723), amyloid PET SUVR with FA GCC (n = 572), tau PET SUVR with WMH% (n = 665), tau PET SUVR with FA GCC (n = 527), and FA GCC with WMH% (n = 575). Source data are provided as a Source Data file. * ADNI = Alzheimer’s Disease Neuroimaging Initiative, ADRC = Mayo Alzheimer’s Disease Research Center, FA GCC = fractional anisotropy in the genu of the corpus callosum, MCSA = Mayo Clinic Study of Aging, SUVR = standardized uptake value, WMH% = white matter hyperintensity volume scaled as % of total intracranial volume.

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