Fig. 3: Cryo-EM structure of human DGAT1 in complex with DGAT1IN1.
From: Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis
a Ribbon representation of the human DGAT1 structure bound to DGAT1IN1 (blue sticks), viewed along the membrane plane and from the cytosolic side. The green surface represents the EM density of DGAT1IN1. b Zoomed-in view of intermolecular interactions between DGAT1IN1 with DGAT1. The EM density of DGAT1IN1 is shown as a green surface. Residues interacting with DGAT1IN1 are shown in purple. The catalytic residue His415 and Asn378 are labeled in red. c Two-dimensional interaction diagram for DGAT1IN1. Polar interactions are shown with dashed lines. Residues participating in non-polar interactions with the inhibitor are shown as spiked arcs.
