Fig. 1: Overall structure and unique features of LY237-GPR84-Gαi complex. | Nature Communications

Fig. 1: Overall structure and unique features of LY237-GPR84-Gαi complex.

From: Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84

Fig. 1

a, b Cryo-EM density map (a) and ribbon presentation (b) of the LY237-GPR84-Gαi complex. The complex density map is shown at a level of 0.06, and the micelle density map is shown at a level of 0.15. c Side view (left panel), and top view (right panel) of the distinct ECL2 (hot pink), N-terminus (light pink) conformation and disulfide bridge of GPR84. d The local density and ribbon presentation of the C11NT-C166ECL2 disulfide bridge. e Dose-response curves of LY237 in activating GPR84 with mutations in the disulfide bridges with cAMP assay. Data are shown as mean ± S.E.M. from a minimum of three technical replicates, which performed in triplicates. The representative dose-response curves are shown. Source data are provided as a Source data file.

Back to article page