Fig. 2: LY237-binding pocket of GPR84.

a Hydrophilic (blue) and hydrophobic (yellow) properties of LY237-binding pocket of GPR84. b Detail interactions between LY237 and GPR84. c Highlighted polar interactions between the polar head of LY237 and GPR84. d Non-polar interactions between the pyridine head of LY237 and key residues from GPR84. e Hydrophobic tail of GPR84 sat at the cleft between TM3-5 and hold by F152^4.57, L182^5.42. f–h Dose-response curves of LY237 in activating GPR84 with mutations in the binding pocket with cAMP assay. Data are shown as mean ± S.E.M. from a minimum of three technical replicates, which performed in triplicates. The representative dose-response curves are shown. Source data are provided as a Source data file.