Fig. 1: PRS preparation and analyses steps.
From: Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups
The left panel shows the GWAS summary statistics, LD reference panels, computational procedures and PRS standardization involved in PRS preparation. The right panel describes the major analytic steps and their associated hypotheses. BBJ Biobank Japan, COGENT Continental Origins and Genetic Epidemiology Network, GWAS genome-wide association study, LD linkage disequilibrium, LDPred Bayesian PRS method (LDPred2 is a specific software implementation of the LDPred algorithm), MGB Mass General Brigham, MVP Million Veteran Program, PRS-CSx continuous shrinkage cross-population PRS method, PRS polygenic risk score, PRSice2 software for computing PRS based on the clumping & thresholding methodology, TOPMed Trans-Omics for Precision Medicine, UKBB + ICBP United Kingdom biobank and the International Consortium of Blood Pressure.
