Fig. 1: Methods for the selective transformation of less reactive carbonyl compounds. | Nature Communications

Fig. 1: Methods for the selective transformation of less reactive carbonyl compounds.

From: Chemoselectivity change in catalytic hydrogenolysis enabling urea-reduction to formamide/amine over more reactive carbonyl compounds

Fig. 1

a Reactivity order of carbonyl compounds27. b Indirect synthetic approaches by protection-deprotection strategy. c Amide-selective catalytic reduction using hydrosilanes or dihydrogen. d Catalytic hydrogenolysis of urea functionality into methanol and two molecules of amines. e Chemoselective hydrogenolysis of urea derivatives into formamides and amines and unprecedented reactivity order of carbonyl compounds (This work).

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