Fig. 7: Ligand–receptor interaction analysis between the four main cell types in psoriatic skin.

a Heatmap showing the number of ligand–receptor pairs with a higher score in PP compared to NS among the cell types. The ligands were expressed by the cell types in the row, and the receptors were expressed by the cell types in the column. The color scale represents the number of ligand–receptor pairs. b Scatter pie plot showing the relative adjacency of the cell types identified in spatial-seq. c Heatmap showing the number of neighbors for each pair of cell types. d Circos plot showing the cytokine and growth factor ligand–receptor interactions with a higher score in PP compared to NS. The ligands are expressed by the keratinocytes, the receptors are expressed by the other cell types. e Circos plot showing the cytokine and growth factor ligand–receptor interactions with a higher score in PP compared to NS. The ligands are expressed by the fibroblasts, the receptors are expressed by the other cell types. f Circos plot showing the cytokine and growth factor ligand–receptor interactions with a higher score in PP compared to NS. The ligands are expressed by the myeloid cells, the receptors are expressed by the other cell types. g Circos plot showing the cytokine and growth factor ligand–receptor interactions with a higher score in PP compared to NS. The ligands are expressed by the T cells, the receptors are expressed by the other cell types.