Fig. 6: Single-cell RNASeq analysis of alveolar cells in SARS-CoV-2 infected hamsters. | Nature Communications

Fig. 6: Single-cell RNASeq analysis of alveolar cells in SARS-CoV-2 infected hamsters.

From: Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2

Fig. 6: Single-cell RNASeq analysis of alveolar cells in SARS-CoV-2 infected hamsters.The alternative text for this image may have been generated using AI.

Single-cell RNA-Seq data set (GSE162208) from lungs of SARS-CoV-2 infected hamsters at 5 (a–e) or 14 (f–j) days post infection (dpi). a, f Expression of alveolar pneumocyte type 1 (AT1) marker gene Rtkn2 (green) and alveolar pneumocyte type 2 (AT2) marker gene Lamp3 (orange). b, g Cells were re-clustered at 5 and 14 dpi resulting in 7 and 11 clusters, respectively. c Rtkn2 mean expression level among clusters at 5 dpi. d Lamp3 mean expression level among clusters at 5 dpi. e Rtkn2 and Lamp3 mean expression level among clusters at 5 dpi. h Rtkn2 mean expression level among clusters at 14 dpi. i Lamp3 mean expression level among clusters at 14 dpi. j Rtkn2 and Lamp3 mean expression level among clusters at 14 dpi. Bar plots indicate mean expression, c, d, h, i red: significant mean gene expression (multiple testing adjusted p value < 0.05); gray: not significant mean gene expression, y axis: mean gene expression level; x axis: cluster number.

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