Fig. 2: Hormone-responsive functional signatures in the epithelium of human breast fibroadenomas. | Nature Communications

Fig. 2: Hormone-responsive functional signatures in the epithelium of human breast fibroadenomas.

From: Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets

Fig. 2: Hormone-responsive functional signatures in the epithelium of human breast fibroadenomas.

a GO analysis of differentially expressed genes in epithelial cells between fibroadenoma and normal tissue. one-sided, hypergeometric test and adjusted by Benjamini-Hochberg correction. b Heatmap of hormone-responsive gene expression between fibroadenomas (FA) and normal tissue (N). c Violin plots showing the expression of genes from (b) in the epithelial cells (N: n = 3173; FA: n = 3173) of fibroadenomas and normal tissues from the single-cell analysis. ****p < 0.0001, two-sided, Wilcoxon test. d Immunohistochemical staining or immunofluorescence staining of genes in (c). Scale bar: 100 μm (IHC), 50 μm (IF). e Scatter diagram of immunohistochemical staining or immunofluorescence staining in (d) between fibroadenomas (FA) and normal tissues (N). Data are expressed as the mean +/− s.e.m. Each dot represents one patient. ****p = 0.0000001 (ER, N: n = 3; FA: n = 9), **p = 0.0021 (PR, N: n = 3; FA: n = 3), ****p = 0.000012 (TFF3, N: n = 7; FA: n = 7), ***p = 0.0008 (PRLR, N: n = 3; FA: n = 4), **p = 0.0014 (TFF1, N: n = 3; FA: n = 3), ***p = 0.0005 (KIAA1324, N: n = 5; FA: n = 5), unpaired two-tailed Student’s t test. Source data are provided as a Source data file.

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