Fig. 1: BOLD and SEEG white matter FC are correlated in a single participant.
a The time series of the two white matter contacts were highly synchronized in both BOLD and SEEG (1–4 Hz) data, suggesting an FC between the two contacts. The MNI coordinates of the two contacts were (46, −14, −20) and (34, −4, −23), respectively. We defined ROIs as spheres with the contact as the center and a radius of one voxel for the BOLD FC calculation. b Matrices of BOLD and SEEG (1–4 Hz) FC between every two white matter contacts. c BOLD and SEEG white matter FC were significantly correlated across all regional pairs in b (Spearman’s rank correlation r(1081) = 0.32, pFDR = 1.2e-25, two-sided). Each point indicated one pair of regions. The Euclidean distances between pairs of regions were regressed out from both BOLD and SEEG FC, and the acquired residuals were used to evaluate the correlation. The shaded envelope denotes the 95% confidence interval. d The correlation between BOLD and SEEG FC was significant after regressing out the distances from both FC in all frequency bands (1–4 Hz: Spearman’s rank correlation r(1081) = 0.32, pFDR = 1.2e-25; 4–8 Hz: r(1081) = 0.13, pFDR = 4.1e-05; 8-13 Hz: r(1081) = 0.17, pFDR = 1.7e-08; 13-30 Hz: r(1081) = 0.32, pFDR = 2.7e-25; 30–40 Hz: r(1081) = 0.37, pFDR = 6.5e-35; 40–70 Hz: r(1081) = 0.32, pFDR = 2.7e-25; 70–170 Hz: r(1081) = 0.33, pFDR = 1.2e-27, all two-sided). The symbol (**) represents pFDR < 0.001. Notably, while only one participant was analyzed here, the p values were corrected with false discovery rate (FDR) to account for multiple comparisons across all participants and all frequency bands in this study. BOLD blood-oxygenation-level-dependent, SEEG stereotactic EEG, FC functional connectivity, ROI region of interest. Source data are provided as a Source Data file.
