Fig. 3: White matter structural connectivity constrains both the BOLD and SEEG white matter FC. | Nature Communications

Fig. 3: White matter structural connectivity constrains both the BOLD and SEEG white matter FC.

From: Intracranial electrophysiological and structural basis of BOLD functional connectivity in human brain white matter

Fig. 3

a Matrices of structural connectivity and white matter BOLD FC in sub1. b Scatter plot of the correlation between structural connectivity and white matter BOLD FC using data from a (Spearman’s rank correlation r(511) = 0.16, pFDR = 4.8e-04, two-sided). The shaded envelope denotes the 95% confidence interval. c The correlations between structural connectivity and white matter BOLD FC for all 16 participants (median Spearman’s rank correlation r = 0.30). See Table S12 for r and pFDR for all participants. False discovery rate (FDR) correction was applied to account for multiple comparisons across all participants. d Matrices of structural connectivity and SEEG white matter FC with data filtered at 1–4 Hz in sub1. e Scatter plot of the correlation between structural connectivity and SEEG white matter FC using data from d (Spearman’s rank correlation r(511) = 0.36, pFDR = 5.6e-15, two-sided). The shaded envelope denotes the 95% confidence interval. f The median Spearman’s rank correlations between structural connectivity and SEEG white matter FC across all 16 participants were higher than r = 0.22 in each frequency band (1–4 Hz: median r = 0.22; 4–8 Hz: median r = 0.23; 8–13 Hz: median r = 0.31; 13–30 Hz: median r = 0.34; 30–40 Hz: median r = 0.33; 40–70 Hz: median r = 0.33; 70–170 Hz: median r = 0.31). See Table S13 for r and pFDR for all participants and all frequency bands. Notably, the Euclidean distances between pairs of regions were regressed out from structural connectivity, SEEG FC, and BOLD FC before evaluating the correlations between matrices. FDR correction was applied to account for multiple comparisons across all participants and all frequency bands. In panels c and f, boxes denote the 25th to 75th percentile and the median line, and whiskers extend 1.5 times the interquartile range from the edges of the box. See Table S1 for the number of each participant’s nonzero structural connections, which defined the sample size of the correlation analysis for each participant. BOLD blood-oxygenation-level-dependent, SEEG stereotactic EEG, FC functional connectivity, DSI diffusion spectrum imaging, SC structural connectivity. Source data are provided as a Source Data file.

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