Fig. 1: TASTPM mice develop less allodynia than WT in the K/BxN serum transfer model of arthritis. | Nature Communications

Fig. 1: TASTPM mice develop less allodynia than WT in the K/BxN serum transfer model of arthritis.

From: Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer’s disease

Fig. 1

a Schematic overview of study design. b Ankle thickness and c clinical scores of fore and hind paws in WT and TASTPM. d Reduced mechanical hypersensitivity (PWT paw withdrawal thresholds) in TASTPM after K/BxN ST. Data represent mean ± SEM, n = 12 mice per group. *p < 0.05, ***p < 0.001 compared to same-day WT or TASTPM Control ST, †p < 0.05, ††p < 0.01, †††p < 0.001 compared to same-day WT K/BxN ST, two-way RM ANOVA, Tukey’s multiple comparisons test. e Representative images of c-Fos+ neurons in dorsal horns. Scale bar, 100 μm. f Quantification of c-Fos+ neurons. Data represent mean ± SEM, n = 8 mice per group (4 per sex). ns not significant, ****p < 0.0001, ††p = 0.0073. Two-way ANOVA, Tukey’s multiple comparisons test.

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