Fig. 1: The IFS and OFS of MFSD2A.
From: Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A
a Two views of ggMFSD2A in the IFS (PDBID: 7MJS14) from the plane of the membrane, related by a 180° rotation. TMs 2, 5, 8 and 11 are shown in blue, orange, red and green, respectively. The remainder of the protein is coloured in light grey. The substrate, LPC-18:3, is shown in surface representation. b Detailed view of the central region in the IFS highlighting (as pink sticks) the central charged residues E312 and R85, the Na+ binding site residue D92, and the IC gate residues, M182, F399 and W403. All TMs except TMs 2, 5, 7, 8, 10 and 11 are omitted for visual clarity. c, d The equivalent of panels a and b, respectively, for the homology model of ggMFSD2A in the OFS. The locations of the EC vestibule and central region are highlighted in panels a and c with rectangular boxes.
