Fig. 2: Pathways for LPC-18:1 entry into the MFSD2A central region.
From: Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A
a Superposition of LPC-18:1 phosphorus (P) atom in the MD trajectory frames shown as spheres. Only positions within 5 Å of the protein are included, and the atoms penetrating the central region from the two different pathways, TM5/TM8 and TM2/TM11 are coloured in grey and yellow, respectively. The protein is otherwise represented as in Fig. 1. b The same as in panel a rotated by 90° to provide the view from the EC side. c Histogram of the minimum z-directional distance between LPC-18:1 P and the Cα of F399 (dz, z = 0 represents z-position of the Cα atom of F399). d–f The same representations as in panels a-c only for the P of POPC from the MD simulations of ggMFSD2A in a pure POPC membrane. g Comparison of the chemical structures of LPC-18:1 and POPC.
