Fig. 5: The LPC-18:1 hydrocarbon tail dynamically samples the EC vestibule upon insertion. | Nature Communications

Fig. 5: The LPC-18:1 hydrocarbon tail dynamically samples the EC vestibule upon insertion.

From: Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A

Fig. 5

Temporal evolution of the distances between the ω−1 carbon of the inserted LPC-18:1 hydrocarbon tail and the Cα of both F60 and L333, and between the ω−14 carbon of the inserted LPC-18:1 hydrocarbon tail and the Cα of V395 in a Traj-1 and b Traj-2. Structural snapshots from the specified trajectory segments (labelled I-V) are shown in the respective panels. LPC-18:1 is shown in surface representation and the protein is represented as in previous figures. Numbering of the carbon atoms in the hydrocarbon tails is as per IUPAC nomenclature.

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