Fig. 3: Estimation of the date of OPV exposure from sequence divergence.
From: Asymptomatic immunodeficiency-associated vaccine-derived poliovirus infections in two UK children
The figure represents the number of mutations from Sabin 1 and 3 vaccine strains (GenBank IDs AY184219 and AY184221). Data were adjusted to a linear function for the accumulation of nucleotide substitutions (Y = 0.2708*X − 11764, R2 = 93% for iVDPV1 and Y = 0.2328*X − 10032, R2 = 92% for iVDPV3). The date of initial Sabin 1 (A) and Sabin 3 (B) infection that led to the iVDPV1 and iVDPV3 cases was estimated by simple linear regression extrapolating the line for the evolution rate of nucleotide substitutions backward to 0 genome substitutions. Source data are provided as a Source Data file. OPV oral polio vaccine, iVDPV immunodeficiency-associated vaccine-derived poliovirus.
