Fig. 1: Relevance and substrate promiscuity of AsqJ.
From: Discovery of extended product structural space of the fungal dioxygenase AsqJ
a Structures of the natural products aspoquinolones A (1) and B (2). b Biosynthetic transformation of 3 to quinolone 4 catalysed by AsqJ. c Pathway of AsqJ from 5 to quinazolinones 6. The molecular portions labelled in red get excised in the course of the AsqJ catalytic transformation. d Examples of drugs with quinolone and quinazolinone motifs: levofloxacin (7) and methaqualone (8). e Graphical summary of AsqJ substrate structural alterations evaluated in this study across the quinazolinone (R1 = iso-butyl) and quinolone (R1 = benzyl) pathways.
