Fig. 5: hPXR partially restores the lifespan-extending effects of nomilin in nhr-8 or daf-12 mutants. | Nature Communications

Fig. 5: hPXR partially restores the lifespan-extending effects of nomilin in nhr-8 or daf-12 mutants.

From: Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions

Fig. 5

a–c lifespan curves showing the lifespan-extending effects of nomilin in C. elegans with indicated genotypes. Nomilin extended the lifespan in WT animals overexpressed with vector control (a left) or WT hPXR (a middle), but not hPXRS247R (a hPXR mutant that blocked its binding with nomilin) (a right). Similarly, overexpression of WT hPXR (b, c middle), but not the vector control (b, c left) or hPXRS247R (b, c right), enabled the maximal lifespan extension of nomilin in nhr-8 or daf-12 animals. The detailed data are shown in Supplementary Table S6. d, e, The quantification of gene expression levels in hPXR transgenic nhr-8 (d) and daf-12 (e) mutant C. elegans. (Two-tailed unpaired Student’s t-test, n = 3/each, each sample contains about 1000 worms. The data were shown as means ± SEM).

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