Fig. 4: Scope of the reaction. | Nature Communications

Fig. 4: Scope of the reaction.

From: Enantioselective synthesis of chiral quinohelicenes through sequential organocatalyzed Povarov reaction and oxidative aromatization

Fig. 4: Scope of the reaction.

Scope with respect to (A) aromatic aldehyde 2 and (B) indole 3. Reaction conditions: (1) 1a (0.1 mmol) and 2 (0.4 mmol) in toluene (2 mL) were heated at 110 °C for 12 h. After the mixture was cooled to room temperature, 3 (0.2 mmol) and (S)-A5 (0.005 mmol) were added, and the reaction was allowed to proceed for 12 h. Silica gel column chromatography gave 4. (2) Reaction of 4 and DDQ (0.3 mmol) in DCM (3 mL) at room temperature for 3 h afforded 5.

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