Fig. 7: M1-N3E2M is well tolerated in nonhuman primates. | Nature Communications

Fig. 7: M1-N3E2M is well tolerated in nonhuman primates.

From: Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile

Fig. 7: M1-N3E2M is well tolerated in nonhuman primates.The alt text for this image may have been generated using AI.

a Timeline of the administration schedule. iv, intravenously. b Animals were weighed weekly after treatment initiation. c Animal body temperature, electrocardiographic and blood pressure measurements were conducted on D-3, D1, D5, D20, D43 and D71. MBP, mean blood pressure. d Blood was collected from a subcutaneous vein of the hind limbs of animals on D-3, D1, D6, D21, D44 and D72 for analysis of serum biochemical parameters. ALT, alanine aminotransferase. AST, aspartate aminotransferase. Alb, albumin. Cre, creatinine. e Blood was collected from a subcutaneous vein of the hind limbs of animals on D-3, D1, D6, D21, D44 and D72 for analysis of hematological parameters. WBC, white blood cell. f Analysis of blood coagulation function on D-3, D6, D21, D44 and D72. APTT, activated partial thromboplastin time. g Cytokine and serum C-reactive protein detection. h Complement detection on D-3, D1, D6, D21, D44 and D72. See also Table S3-S6. Source data are provided as a Source Data file.

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