Table 2 Repetitive head impact exposure characteristics of brain donors by CTE status
No CTE (n = 180) | Mild CTE (n = 163) | Severe CTE (n = 288) | All (n = 631) | |
|---|---|---|---|---|
Number of reported concussions, mean (SD) | 67.0 (283.4) | 89.2 (211.0) | 115.1 (350.8) | 94.5 (301.2) |
Concussion number, median (IQR; range) | 15 (6,50; 0,3500) | 20 (7,87; 0,1500) | 25 (9,100; 0,5000) | 20 (7,92; 0,5000) |
Age of first exposure to football (SD) | 10.9 (3.8) | 10.2 (3.6) | 12.1 (2.8) | 11.3 (3.4) |
Duration of football in years (SD) | 9.5 (5.3) | 11.6 (5.0) | 15.0 (5.7) | 12.5 (5.9) |
Highest level of football play (%) | ||||
Pre-high school | 10 (5.6%) | 6 (3.7%) | 1 (0.3%) | 17 (2.7%) |
High school | 60 (33.3%) | 29 (17.8%) | 8 (2.8%) | 97 (15.4%) |
College | 61 (33.9%) | 64 (39.3%) | 81 (28.1%) | 206 (32.6%) |
Semi-professional | 16 (8.9%) | 7 (4.3%) | 4 (1.4%) | 27 (4.3%) |
Professional | 33 (18.3%) | 57 (35.0%) | 194 (67.4%) | 284 (45.0%) |
Position played at highest level (%) | ||||
Defensive back | 10 (5.6%) | 21 (12.9%) | 29 (10.1%) | 60 (9.5%) |
Defensive line | 23 (12.8%) | 26 (16%) | 37 (12.8%) | 86 (13.6%) |
Kicker | 1 (0.6%) | 1 (0.6%) | 0 (0.0%) | 0 (0.0%) |
Linebacker | 14 (7.8%) | 26 (16.0%) | 33 (11.5%) | 73 (11.6%) |
Offensive line | 25 (13.9%) | 23 (14.1%) | 50 (17.4%) | 98 (15.5%) |
Punter | 0 (0.0%) | 2 (1.2%) | 0 (0.0%) | 2 (0.3%) |
Quarterback | 10 (5.6%) | 7 (4.3%) | 13 (4.5%) | 30 (4.8%) |
Running back | 10 (5.6%) | 10 (6.1%) | 52 (18.1%) | 72 (11.4%) |
Tight end | 8 (4.4%) | 4 (2.5%) | 13 (4.5%) | 25 (4.0%) |
Wide Receiver | 5 (2.8%) | 5 (3.1%) | 10 (3.5%) | 20 (3.2%) |
Multiple | 64 (35.6%) | 32 (19.6%) | 48 (16.7%) | 144 (22.8%) |
Other | 4 (2.2%) | 1 (0.6%) | 0 (0.0%) | 5 (0.8%) |
Unknown | 6 (3.3%) | 5 (3.1%) | 3 (0.1%) | 14 (2.2%) |
Participation in other contact/collision sport (%) | 62 (34.4%) | 53 (32.5%) | 55 (19.1%) | 170 (26.9%) |
Military history (%) | 41 (22.9%) | 24 (14.8%) | 82 (28.5%) | 147 (23.4%) |
Military combat exposure (%) | 7 (3.9%) | 7 (4.4%) | 7 (2.4%) | 21 (3.4%) |
Exposure indices | ||||
CHII, mean (SD) | 4,515 (3,199) | 5,553 (3,410) | 7,641 (3,870), | 6,117 (3,815) |
CHII, median (IQR; range) | 3963 (2191,6220; 206,18222) | 4613 (3227,7027; 206,18384) | 6841 (4830,9521; 206,19240) | 5381 (3445,6118; 206,19240) |
CHII-G, mean (SD) | 88,972 (47,178) | 107,650 (41,755) | 148,777 (52,557) | 119,081 (55,451) |
CHII-G, median (IQR; range) | 89,411 (60757,110939; 4246,280130) | 110,054 (82076,131468; 4246,233872) | 145,219 (106432,189016; 4246,310242) | 112,741 (83737,151860; 4246,310242) |
CHII-R, mean (SD) | 6.57 × 106 (4.35 × 106) | 8.32 × 106 (3.72 × 106) | 12.26 × 106 (5.0 × 106) | 9.48 × 106 (5.19 × 106) |
CHII-R, median (IQR; range) | 6.28 × 106 (4.00 × 106,8.30 × 106; 0.25 × 106,29.9 × 106) | 8.16 × 106 (5.81 × 106,10.4 × 106; 0.25 × 106,18.9 × 106) | 12.0 × 106 (8.30 × 106,15.5 × 106; 0.25 × 106.34.7 × 106) | 8.48 × 106 (6.21 × 106,12.69 × 106; 0.25 × 106,34.7 × 106) |
