Fig. 1: Strategy for separation of the condensing and modifying regions of hFASN.
From: Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat
A Schematic representation of the catalytic cycle for de novo fatty acid synthesis in metazoans. B Domain organization and schematic of full length hFASN. Location of the engineered TEV cleavage site is shown by the black-red arrowhead. The expected cleavage fragments are shown at the bottom of the panel.
