Fig. 2: Single-cell analysis data of peripheral blood mononuclear cells (PBMC) from patient 1 (P1) and a healthy control (HC). | Nature Communications

Fig. 2: Single-cell analysis data of peripheral blood mononuclear cells (PBMC) from patient 1 (P1) and a healthy control (HC).

From: Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling

Fig. 2

Plots on the left show uniform manifold approximation and projection (UMAP) visualization of PBMC clusters. B lymphocytes were excluded from further analysis as P1 had been treated with anti-CD20 prior to sample collection. Bar graphs show the distribution of PBMC subpopulations in each sample, defined by surface protein markers using the BD Rhapsody platform. Top up- and down-regulated genes in PBMC subsets of P1 relative to HC are shown in the table. CM central memory, EM effector memory, FC expression fold change, NK natural killer, TEMRA terminally differentiated effector memory T cells re-expressing CD45RA.

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