Fig. 5: Differential gene expression analyses: comparison of NBEAL2 and LRBA-deficient T cells.

a Differential Gene Expression (DEG) analyses between the NBEAL2-deficient cells (N = 5) or LRBA-deficient cells (N = 5) and the healthy controls group (N = 7). IPA Pathways analyses were performed on the T CD4⁺ lymphocytes subsets. In red the DEG correspond to the comparison between NBEAL2 patients and controls. In yellow, the DEG correspond to the comparison between LRBA patients and controls. b Differential Gene Expression (DEG) analyses between the NBEAL2 and LRBA patients’ groups and the healthy controls group. IPA Pathways analyses of the T CD8⁺ lymphocytes subsets. In red the DEG correspond to the comparison between NBEAL2 patients and controls. In yellow, the DEG correspond to the comparison between LRBA patients and controls. c Signature of the STAT3/IL-6 pathway in T cells subsets for the NBEAL2, LRBA and healthy controls groups. The heatmap shows the average signature score for the T cells subsets of each group. The list of genes from the signature Hallmark_IL6_JAK_STAT3_signaling was used. Source data are provided as a Source Data file.