Fig. 4: Orthosteric ligand-binding pocket of α1AAR.
From: Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody
Side view of α1AAR ligand-binding site of noradrenaline (a), oxymetazoline (b), and tamsulosin (c). Residues within 4.1 Å distance of the ligands are shown in stick representation. Hydrogen bonds are shown as yellow dashed lines. d Comparison of residues involved in ligand-binding pockets. e–g Diagram of ligand interactions between α1AAR and the ligands. Residues within 4.1 Å distance of the ligands are shown.
