Fig. 7: Comparison of the receptor-G protein binding interfaces of the adrenergic receptor subtypes.
From: Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody
a Sequence alignments of the carboxyl-terminal α5-helix of G proteins subtypes. b Superimposition of the binding interfaces of α1AAR-miniGsq complexes with α2AAR-Go (PDB ID: 7EJ0) and β2AR -Gs (PDB ID: 3SN6) complexes. The receptors are used for alignment. The proteins are colored as follows: α1AAR (cobalt), miniGsq (pink), α2AAR (yellow), Go (cyan), β2AR (green), and Gs (blue purple). Detailed polar interactions and the equivalent residues of α1AAR-miniGsq (c, d), α2AAR-Go (e, f), and β2AR -Gs (g, h). The polar interactions are shown as black dashed lines.
