Fig. 1: Tau protein sequence and domains. | Nature Communications

Fig. 1: Tau protein sequence and domains.

From: Specific post-translational modifications of soluble tau protein distinguishes Alzheimer’s disease and primary tauopathies

Fig. 1: Tau protein sequence and domains.The alternative text for this image may have been generated using AI.

Amino-acid sequence of the six tau isoforms found in human central nervous system and generated by alternative splicing of MAPT gene exon 2 (encoding for N1 insert), exon 3 (encoding for N2 insert), and/or exon 10 (encoding for MTBR2). Sequences of AQUA-grade isotopically labelled peptides (“AQUA peptides”) used for tau isoform absolute quantification are highlighted in colour. The AQUA peptides specific for the tau microtubule binding repeats  were used for measuring the absolute quantities of total tau (sum of 4R and 3R tau isoforms) in the soluble and insoluble brain extracts. N1 and N2, tau protein projection domain N-terminal insert 1 and 2 respectively. PRR Proline-rich region, MTBR microtubule-binding repeat.

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