Fig. 2: T cell depots alone enhance B16-F10 tumor control. | Nature Communications

Fig. 2: T cell depots alone enhance B16-F10 tumor control.

From: Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors

Fig. 2: T cell depots alone enhance B16-F10 tumor control.The alt text for this image may have been generated using AI.

a Schematic of therapeutic study. b, c Tumor volumes (b) and Kaplan–Meier survival curves (c), with sub-lethal irradiation preconditioning of mice left untreated, injected peritumorally with empty depots, or treated with the following T cell conditions: intravenous T cell delivery, direct peritumoral T cell injection or T cell depots. P-values for c were determined using a log-rank (Mantel–Cox) test. Data are representative of n = 16 mice per condition in two independent experiments (8 mice per group per experiment). d, e Therapeutic study without preconditioning. Tumor growth (d) and Kaplan–Meier survival curves (e) of the indicated conditions. For the ‘Contralateral Injection_T cell Depot’ condition, T cell-loaded depots were injected contralateral to the tumor location. P-values for e were determined by Log-rank (Mantel–Cox) test. Data represent n = 9 mice per condition for a single experiment.

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