Fig. 6: SIVETs enhance long-term tumor control. | Nature Communications

Fig. 6: SIVETs enhance long-term tumor control.

From: Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors

Fig. 6

a Schematic of the experiment. b, c Primary B16-F10 tumor studies. Tumor volumes (b) and Kaplan–Meier survival curves (c) comparing tumor growth and survival of mice treated with the indicated conditions. P-values for c were determined by Log-rank (Mantel–Cox) test. Data represent n = 7 mice for TcellOnly_Depot condition, n = 8 mice for Vax_FLT3L and Vax_GMCSF conditions, and n = 15 mice for NT condition in two independent experiments (7 and 8 mice for individual experiments) and n = 16 mice for SIVET_FLT3L and SIVET_GMCSF conditions (n = 8 mice per experiment). d, e Contralateral tumor re-challenge studies for long-term surviving mice. d Tumor growth (d) and Kaplan-Meier survival curves (e) of mice contralaterally re-challenged with 1 × 105 B16-F10 tumor cells after 120 days of primary tumor challenge. p-values for e were determined by Log-rank (Mantel–Cox) test. Data are representative of n = 10–13 mice per condition in two independent studies. f–h Antigen escape study. f Schematic of therapeutic study for (g, h). Tumor volumes (g) and Kaplan–Meier survival curves (h) comparing tumor growth and survival of mice treated with the indicated conditions. P-values for (h) were determined using a log-rank (Mantel–Cox) test. Data represent n = 8 mice per condition for a single experiment.

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