Fig. 2: TRPV4 channelopathies and cancer mutations in RhoA.
a TRPV4-linked disease-associated mutations mapped onto the structure of a single hTRPV4apo subunit (orange ribbon). Residue positions for disease-causing mutations in dysplasia (skeletal, metatropic, Spondylometaphyseal, or Kozlowski type), peripheral neuropathy (Charcot-Marie-Tooth disease type 2) and arthropathy (Familial digital arthropathy-brachydactyly) are shown as green, dark blue, and light blue spheres, respectively. Mutations causing multiple pathologies (neuropathy, dysplasia, arthropathy, etc.) are colored pink. b Mutations in RhoA associated with cancer. c TRPV4-RhoA interface with the interacting residues shown in sticks. Residues undergoing disease-causing mutations are labeled. Dashed lines represent putative ionic interactions.
