Fig. 3: Susceptibility of P. aeruginosa isolates to phage vFB297 and beta-lactam antibiotics. | Nature Communications

Fig. 3: Susceptibility of P. aeruginosa isolates to phage vFB297 and beta-lactam antibiotics.

From: Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa

Fig. 3: Susceptibility of P. aeruginosa isolates to phage vFB297 and beta-lactam antibiotics.The alternative text for this image may have been generated using AI.

Transmission electron microscopy images of (a) Pakpunavirus vFB297 (top panel) and susceptible D0.4 bacterial cell lysed by vFB297 phage particles (bottom panel). b, c Susceptibility of patient isolates to phage vFB297 was determined by plaque assays (for full dataset, see Supplementary Fig. S2). S susceptible (plaques visible in phage dilutions), I intermediate (plaques visible only in undiluted phage), R resistant (no plaques visible). d–f Susceptibilities to beta-lactam antibiotics of P. aeruginosa isolates from consecutive sputum samples. MIC determinations were performed on three occasions, yielding similar results. MIC breakpoints (EUCAST 2019) for beta-lactams are shown by dashed lines. Each symbol represents a single P. aeruginosa isolate. The seven isolates selected for WGS are represented by closed symbols. Phage treatment courses are indicated by gray-shaded rectangles.

Back to article page