Fig. 2: Multiplicity of infection and heterozygosity. | Nature Communications

Fig. 2: Multiplicity of infection and heterozygosity.

From: Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania

Fig. 2

a Multiplicity of infection (MOI) of 290 DBS samples across 5 districts. The box bounds the IQR divided by the median, and Tukey-style whiskers extend to a maximum of 1.5 × IQR beyond the box. Differences between districts were examined using a two-sided t test. Bonferroni adjusted P values are indicated for significant pairs only. b Correlation of expected heterozygosity of microhaplotypes and drug resistance loci in the global population and the observed heterozygosity in the Zanzibar samples was analyzed using linear regression (R2 = 0.37, F(1, 33) = 19.78, P = 9.292e–5). c Distribution of expected heterozygosity of the 28 microhaplotypes across 5 districts in Zanzibar. The box bounds the IQR divided by the median, and Tukey-style whiskers extend to a maximum of 1.5 × IQR beyond the box. Differences between districts were examined using a pairwise two-sided t test. Bonferroni adjusted P values are indicated for significant pairs only. d Map of Zanzibar archipelago with the 5 districts included in the study. Inset map shows the United Republic of Tanzania. Airports (squares) and ferry terminals (diamonds) are highlighted.

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