Table 1 hPSC lines used for the study
Line ID | Name used in this study | Sex | Genotype | Location of deletions | Diagnosis | Single-cell RNA sequencing | Calcium Imaging | IHC |
|---|---|---|---|---|---|---|---|---|
NRXN1 cKO hESCs | Flp (Ctrl)/Cre (Het) | M | NRXN1αβ deletion | Chr2:50,236,754-50,237-130 (hg38) | None | Yes | Yes | Yes |
C3141a iPSC | Ctrl.1 | M | Control | – | None | Yes | No | No |
C9632 iPSC | Ctrl.2 | F | Control | – | None | Yes | Yes | Yes |
C8905a iPSC | Ctrl.3 | M | Control | – | None | Yes | Yes | Yes |
C2320b iPSC | Ctrl.4 | M | Control | – | None | Yes | No | No |
N3320a iPSC | NRXN1del1 | M | NRXN1α deletion | Chr2:50,899,162-51,081,962 (hg38) | SCZ | Yes | No | No |
N9540a iPSC | NRXN1del2 | F | NRXN1αβ deletion | Chr2:50,346,562-51,397,924 (hg38) | SCZ | Yes | Yes | Yes |
N1884a iPSC | NRXN1del3 | M | NRXN1α deletion | Chr2:50,979,562-51,087,962 (hg38) | SCZ | Yes | Yes | Yes |
N0575a iPSC | NRXN1del4 | F | NRXN1α deletion | Chr2:50,327,035-50,812,247(hg38) | SCZ | Yes | No | No |
