Fig. 4: Specific interactions between Pygo2 and ChiLS. | Nature Communications

Fig. 4: Specific interactions between Pygo2 and ChiLS.

From: Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome

Fig. 4: Specific interactions between Pygo2 and ChiLS.

Coloring as in Fig. 3, except for green, marking second SSBP2 molecule. a Hydrophobic interactions formed between Pygo2 NPF and its cognate surface of ChiLS; left, ribbon representation; right, electrostatic surface representation. b Interface residues mediating interactions between Pygo2 PPP and SSBP2. c Hydrogen bonds and salt bridges between the negatively charged side chains of conserved glutamic acid (E) or aspartic acid (D) residues 3’ adjacent to Pygo2 NPF (see also Fig. 2a) and the guanidium or carboxamide groups in the sidechains of conserved arginine (R) or asparagine (N) residues of LDB1.

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