Fig. 3: Subthreshold Vm delta rhythm structures Vm and LFP beta power.
From: Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice
a Mean intraburst firing frequency for delta-rhythmic ChIs and SYNs (independent t-test, p = 0.007, n = 31, df = 29). b Example voltage trace of a delta-rhythmic striatal neuron with corresponding Vm wavelet power spectrum shown below. c Mean normalized Vm spectral power aligned to the peak of all spikes in the example neuron shown in b. d–f Vm power around spike peak relative to pre-spike period (−200 to −100 ms) for (d) delta-rhythmic ChIs (n = 21), (e) delta-rhythmic SYNs (n = 9), and (f) non-delta rhythmic SYNs (n = 16). g Quantification of Vm power around spike peak relative to pre-spike period at beta-frequencies (20–40 Hz) for delta-rhythmic (D, red) and non-delta (ND, blue) ChIs (left), and SYNs (right). Vm beta power at spike peak was significantly higher than pre-spike period in all groups (all one-sample t-test, ChI D: p = 1.7 × 10−5, df = 21; SYN D: p = 5.3 × 10−5, df = 8; SYN ND: p = 0.015, df = 15). Delta-rhythmic SYNs showed greater modulations than non-delta SYNs (independent t-test SYN D vs SYN ND: p = 3.64 × 10−4, n = 25, df = 23). h–j Spike-aligned LFP power (relative to pre-spike period) for (h) delta-rhythmic ChIs (n = 21), (i) delta-rhythmic SYNs (n = 9), and (j) non-delta SYNs (n = 16). k Quantification of LFP power around spike peak relative to pre-spike period at beta frequencies for delta-rhythmic (red) and non-delta (blue) ChIs (left), and SYNs (right). LFP beta power at spike peak was significantly higher than pre-spike period in all groups (all one-sample t-test, ChI D: p = 8.9 × 10−5, n = 22, df = 21; SYN D: p = 0.0147, n = 9, df = 8; SYN ND: p = 0.04, n = 16, df = 15), and delta-rhythmic SYNs showed greater modulations than non-delta SYNs (independent t-test SYN D vs SYN ND: p = 0.037, n = 25, df = 23). Quantifications are visualized as violin plots with the outer shape representing the data kernel density and a box-and-whisker plot (box: interquartile range, whiskers: 1.5x interquartile range, white line: mean). All statistical tests are two-sided. Source data are provided as a Source Data file.
