Fig. 5: Delta-rhythmic ChIs and SYNs exhibit distinct, locomotion-dependent temporal relationships to LFP delta, beta, and gamma oscillations.
From: Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice
a LFP power during rest (pink) and movement (green). b Spike-LFP PLVu2 during rest (pink) and movement (green) for delta-rhythmic neurons. Yellow dots mark a significant difference between rest and movement periods (p < 0.05). c Same as b, but for non-delta neurons. d Quantification of spike-LFP PLVu2 difference at delta frequencies (1–4 Hz) between rest and movement. Only delta-rhythmic (D) ChIs (red) exhibit enhanced spike-LFP PLVu2 during movement (all one-sample t-test, ChI D: p = 0.008, n = 21, df = 20; one neuron was excluded due to the lack of movement data; SYN D: p = 0.068, n = 9, df = 8; SYN ND: p = 0.91, n = 16, df = 15), while delta-rhythmic SYNs have similar firing rate modulation as non-delta SYNs (independent t-test SYN D vs SYN ND: p = 0.09, n = 25, df = 23). e–g Population spike-aligned LFP spectral power difference between rest and movement for (e) delta-rhythmic ChIs, (f) delta-rhythmic SYNs, and (g) non-delta SYNs. h Quantification of normalized LFP power difference between rest and movement for delta-rhythmic ChIs and SYNs (red), and non-delta SYNs (blue) in the beta range (20–40 Hz; One ChI was excluded due to the lack of movement data. Within-group comparison, all one-sample t-test, ChI D: p = 0.97, n = 21, df = 20; SYN D: p = 0.004, n = 9, df = 8; SYN ND: p = 0.4, n = 16, df = 15; Between-group comparison, independent t-test, SYN D vs SYN ND: p = 0.005, n = 25, df = 23) and high-gamma range (70–100 Hz, Within-group comparison, all one-sample t-test, ChI D: p = 0.019, n = 21, df = 20, SYN D: p = 0.054, n = 9, df = 8; SYN ND: p = 0.51, n = 16, df = 15; Between-group comparison, independent t-test, SYN D vs SYN ND: p = 0.45, n = 25, df = 23).All shaded regions around line plots represent the standard error of the mean. Quantifications are visualized as violin plots with the outer shape representing the data kernel density and a box-and-whisker plot (box: interquartile range, whiskers: 1.5x interquartile range, white line: mean). All statistical tests are two-sided. Source data are provided as a Source Data file.
