Fig. 1: TET2/3 play a role in SI homeostasis.
From: TET2 and TET3 loss disrupts small intestine differentiation and homeostasis
a Hematoxylin and Eosin (H&E)-stained histologic images of the jejunum from Tet2/3fl/fl (wt) and Tet2/3fl/fl VillinCre (dko) mice. Scale bar 100 µm (upper) and 50 µm (lower). b, c Statistical analysis of crypt length (b) and crypt width (c) of wt (n = 5) and dko (n = 5) SI. d Statistical analysis of crypts number in wt (n = 5) and dko (n = 5) SI-jejunum. Statistical analysis of villus length (e) and villus width (f) of wt (n = 5) and dko (n = 5) SI. g Immunohistochemical staining for LYZ1, CHGA, DCLK1, Alcian Blue (AB) and periodic acid-schiff stain (PAS) of the SI from dko mice, compared with wt mice. Scale bar 50 µm. h Quantification of CHGA -positive cells in wt (n = 5) and dko (n = 5) mice. i Quantification of DCLK1-positive cells in wt (n = 5) and dko (n = 6) mice. Significance (b–i) was determined using a two-sided t-test and is expressed as the mean ± SEM. Source data are provided as a Source Data file.
