Fig. 3: Top synergistic combination across anchors.

A–F The impact score for each combination is plotted with median synergy score of a given combination across cell lines compared to the median synergy score of all other pairs for that anchor represented on the X axis (as the Log10 ratio of median scores) and statistical enrichment of synergies for the plotted combination over all other tested combinations (with the same anchor) represented on the Y axis. The size of the dots represents the percentile of synergy scores for a given combination falling within the top 5% of all synergy scores for the whole screen (all anchors). Each plot corresponds to a different anchor drug: A AZD7762 (CHK1/2) B Olaparib (PARP) C Pemetrexed (anti-folate); D trametinib (MEK1/2) E alpelisib (PI3Kalpha) F navitoclax (BCL2). G Overview of the top combinations based on impact score FDR and percentile of events (cell lines presenting with synergy) in the top 5% of all synergy scores (across all anchors: strong synergies). Combinations with at least 15% of strong synergistic events are shown (15% of the synergy scores across cell lines for that drug pair fall in the top 5% synergy scores overall). The size of the dots corresponds to percentile of events in the top 5% and color shade to the statistical enrichment (FDR).