Fig. 2: Reaction arrays executed with the phactor™ software.
From: Rapid planning and analysis of high-throughput experiment arrays for reaction discovery
The reaction array design and results are shown here as displayed on phactor™. Colour bars adjacent to compound numbers correspond to the colour bars in the reaction array design grid generated by phactor™. Product/internal standard ratios are calculated using the observed UV-derived peak area, while assay yields account for differences in product absorptivity by calibrating to authentic samples of products. a Preliminary esterification hit leading to publication53. b Optimized oxidative indolization conditions towards the synthesis of umifenovir54. c Allylation catalyst/ligand concentration ratio and base reaction array analysed by conversion and selectivity.
